B vitamins specifically vitamin B9 helps in cell building and maintains DNA. It promotes the growth of red blood cells. It also helps to reduce the risk of birth defects and activated vitamin B12 helps regulate the nervous system and helps in red blood cell formation. People can get B Vitamins from their balanced diet filled with delicious foods naturally rich in B vitamins but as Vitamin B is soluble in water they need to taken as Vitamin B complex.
Firstly, we need to understand how activated B vitamins are different from non-activated B vitamins.
Activated vitamins are readily available to be utilized by the body as they do not have to be broken down and manufactured by the body into a usable form as is the case with the inactive vitamins. This is beneficial if there is a problem with the process of digestion or if some enzymatic functions are lacking in some way. Activated vitamins are important co-factors for many body processes. In the case of Pyridoxal-5-Phosphate (P-5-P or activated B6) it is involved in more than 80% of reactions in the neurochemistry of the brain but it requires one-step process of re-adding a phosphate group before it becomes active. Whereas, non-activated B vitamins require some form of metabolic or enzymatic conversion to be made usable by our body.
Activated B vitamins may be beneficial for those who:
Are fond of consuming refined or processed foods
Consume medicines that deplete B vitamins
Have issues related to digestive system
Have MTHFR polymorphisms
People having methylene-tetrahydrofolate reductase (MTHFR) polymorphisms need B Vitamins as MTHFR gene is responsible for the production of the MTHFR enzyme which allows correct metabolism of B9 and in combination with vitamin B12, works as a methyl group donor in a wide variety of metabolic and nervous system processes.
Many gene variations can affect B9 (folate) metabolism and significantly increase the risk of B9 deficiency in affected individuals, even if they are taking recommended daily intakes.
The most common MTHFR mutations that affect genes are:-
MTHFR C677T and MTHFR A1298C. Mutations can occur on different locations of these genes and be inherited from only one or both parents. Having one mutated genes is related to risk of certain health problems but having two increases the risk much more.
An MTHFR gene mutation can change the metabolic activities in some people and convert important nutrients from their diets into active vitamins, minerals and proteins. Genetic mutations can also alter neurotransmitter and hormone levels. In some cases this enzyme can affect health parameters, such as cholesterol levels, brain function, digestion, endocrine functions.
B vitamins as a group help to maintain:
Energetic and healthy body
Happy and stress free life
Prevents Memory Loss and Lowers Risk of Neurodegenerative Disease
Helps to keep nervous system healthy
Required for Healthy Skin and Hair
Help Prevent Cancer and Anemia
Good cardiovascular system
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